13-Oxa-2,6,11-triazapentadecanoic acid, 6-[3-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]propyl]-14, 14-dimethyl-12-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 13-Oxa-2,6,11-triazapentadecanoic acid, 6-[3-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]propyl]-14, 14-dimethyl-12-oxo-, 1,1-dimethylethyl ester
• CAS No.: 140652-58-0
• Molecular Formula: C₃₄H₅₉Cl₂N₅O₅
• Molecular Weight: 688.779
• Mol file: 140652-58-0.mol

Synonyms:

Chemical Property of 13-Oxa-2,6,11-triazapentadecanoic acid, 6-[3-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]propyl]-14, 14-dimethyl-12-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-Oxa-2,6,11-triazapentadecanoic acid, 6-[3-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]propyl]-14, 14-dimethyl-12-oxo-, 1,1-dimethylethyl ester

There total 5 articles about 13-Oxa-2,6,11-triazapentadecanoic acid, 6-[3-[[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutyl]amino]propyl]-14, 14-dimethyl-12-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) → {4-[[3-(4-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propyl]-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester (140652-58-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent

3: H₂ / Raney Ni

With hydrogen; nickel;

DOI:10.1039/c39920000298

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → {4-[[3-(4-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propyl]-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester (140652-58-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent

3: H₂ / Raney Ni

With hydrogen; nickel;

DOI:10.1039/c39920000298

Reference yield:

N1,N8-bis(tert-butoxycarbonyl)spermidine (83392-10-3) → {4-[[3-(4-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-butyrylamino)-propyl]-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester (140652-58-0)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂ / Raney Ni

With hydrogen; nickel;

DOI:10.1039/c39920000298

upstream raw materials:

chlorambucil chloride

{4-[(3-Amino-propyl)-(3-tert-butoxycarbonylamino-propyl)-amino]-butyl}-carbamic acid tert-butyl ester

N-(3-aminopropyl)-1,4-diaminobutane

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Downstream raw materials:

N-<3-aminopropyl>-4-phenylbutanamide