2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole

Base Information

• Chemical Name: 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole
• CAS No.: 51052-10-9
• Molecular Formula: C₁₇H₁₇N₃
• Molecular Weight: 263.342
• Mol file: 51052-10-9.mol

Synonyms:

Chemical Property of 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole

There total 4 articles about 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole (51052-10-9)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 2 h / 40 °C / Inert atmosphere

3: hydrogenchloride / water / 6 h / Inert atmosphere; Reflux

4: thionyl chloride / chloroform / 3 h / Inert atmosphere; Reflux

5: potassium carbonate / acetonitrile / 10 h / Inert atmosphere; Reflux

With hydrogenchloride; thionyl chloride; hydrazine hydrate; potassium carbonate; In ethanol; chloroform; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1016/j.ejmech.2019.111881

Reference yield:

2-[2-(hydroxymethyl)-1H-benzimidazol-1-yl]ethanol (102000-86-2) → 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole (51052-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / chloroform / 3 h / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 10 h / Inert atmosphere; Reflux

With thionyl chloride; potassium carbonate; In chloroform; acetonitrile;

DOI:10.1016/j.ejmech.2019.111881

Reference yield:

2-[(2-nitrophenyl)amino]ethanol (4926-55-0) → 2-benzyl-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole (51052-10-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 2 h / 40 °C / Inert atmosphere

2: hydrogenchloride / water / 6 h / Inert atmosphere; Reflux

3: thionyl chloride / chloroform / 3 h / Inert atmosphere; Reflux

4: potassium carbonate / acetonitrile / 10 h / Inert atmosphere; Reflux

With hydrogenchloride; thionyl chloride; hydrazine hydrate; potassium carbonate; In ethanol; chloroform; water; acetonitrile;

DOI:10.1016/j.ejmech.2019.111881

upstream raw materials:

2-[(2-nitrophenyl)amino]ethanol

ortho-nitrofluorobenzene

2-[2-(hydroxymethyl)-1H-benzimidazol-1-yl]ethanol