3-(benzoylamino)-4-methylbenzoic acid

Base Information

• Chemical Name: 3-(benzoylamino)-4-methylbenzoic acid
• CAS No.: 401828-76-0
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.273
• Mol file: 401828-76-0.mol

Synonyms:

Chemical Property of 3-(benzoylamino)-4-methylbenzoic acid

Chemical Property:

• Boiling Point: 367.2±35.0 °C(Predicted)
• PKA: 4.35±0.10(Predicted)
• Density: 1.295±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-(Benzoylamino)-4-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzoylamino)-4-methylbenzoic acid

There total 2 articles about 3-(benzoylamino)-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-p-toluic acid (2458-12-0) → 3-benzoylamino-4-methyl-benzoic acid (401828-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / 0 °C / Reflux

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: sodium hydroxide; water / methanol / 2 h / 50 °C

With thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.5b01478

Reference yield:

3-amino-4-methyl benzoic acid methyl ester (18595-18-1) → 3-benzoylamino-4-methyl-benzoic acid (401828-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: sodium hydroxide; water / methanol / 2 h / 50 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.5b01478

Reference yield:

3-benzoylamino-4-methyl-benzoic acid (401828-76-0) → 3-benzamido-4-methylbenzohydroxamate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: hydroxylamine / tetrahydrofuran; methanol

With hydroxylamine; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/acs.jmedchem.5b01478

upstream raw materials:

3-amino-p-toluic acid

3-amino-4-methyl benzoic acid methyl ester