2-(4-methylphenyl)propanedioic acid

Base Information

• Chemical Name: 2-(4-methylphenyl)propanedioic acid
• CAS No.: 118459-49-7
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Mol file: 118459-49-7.mol

Synonyms:

Chemical Property of 2-(4-methylphenyl)propanedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylphenyl)propanedioic acid

There total 4 articles about 2-(4-methylphenyl)propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-bromotoluene (106-38-7) → 2-(4-methylphenyl)propanedioic acid (118459-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.03 h / Inert atmosphere

1.2: 48 h / 70 °C / Inert atmosphere

2.1: sodium hydroxide / water; diethyl ether / Inert atmosphere

With sodium hydride; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; mineral oil;

DOI:10.1002/chem.201800641

Reference yield:

diethyl 2-(4-methylphenyl)propane-1,3-dioate (29148-27-4) → 2-(4-methylphenyl)propanedioic acid (118459-49-7)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; Inert atmosphere;

DOI:10.1002/chem.201800641

Reference yield:

methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) → 2-(4-methylphenyl)propanedioic acid (118459-49-7)

Guidance literature:

anschliessendes Behandeln mit aether. Isopropylmagnesiumchlorid-Loesung und erneuten Einleiten von Kohlendioxid;

DOI:10.1007/BF03344001

upstream raw materials:

methylammonium carbonate

para-bromotoluene

diethyl 2-(4-methylphenyl)propane-1,3-dioate

Refernces

• 1、 -. "Pyrimidinium compound, and preparation method and application thereof". Paragraph 0341-0344; 0349. . Retrieved 2020/06/05.