ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

Base Information

Chemical Name:ethyl 2-(3-chlorophenyl)-2-hydroxyacetate
CAS No.:1011488-42-8
Molecular Formula:C₁₀H₁₁ClO₃
Molecular Weight:214.649
Hs Code.:

Synonyms:

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Chemical Property of ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

Chemical Property:

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Technology Process of ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

There total 3 articles about ethyl 2-(3-chlorophenyl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62123-73-3
ethyl 2‐(3‐chlorophenyl)‐2‐oxoacetate

: 1011488-42-8
ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

Guidance literature:: With C₅₂H₈₉N₂O₁₇⁽¹⁺⁾*CH₃O₃S^(1-); hydrogen; acetic acid; In n-heptane; toluene; at 30 ℃; for 3h; under 15001.5 Torr; enantioselective reaction; Catalytic behavior; Autoclave;
DOI:10.1039/c7cc00892a

Reference yield:

: 16273-37-3,32222-43-8,52950-16-0,61008-98-8
3-chloromandelic acid

: 190433-57-9
(S)-ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

: 1011488-42-8
ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 3 h / Reflux

2: Dess-Martin periodane / dichloromethane / 0 °C

3: cyclohexanone monooxygenase mutant L₁₄₃F from Acinetobacter sp. NCIMB 9871 in Escherichia coli whole-cell culture medium / acetonitrile / 20 °C / Inert atmosphere; Microbiological reaction; Enzymatic reaction

With Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; acetonitrile;
DOI:10.1002/anie.201907606

Reference yield:

: 54395-28-7
ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

: 190433-57-9
(S)-ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

: 1011488-42-8
ethyl 2-(3-chlorophenyl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 0 °C

2: cyclohexanone monooxygenase mutant L₁₄₃F from Acinetobacter sp. NCIMB 9871 in Escherichia coli whole-cell culture medium / acetonitrile / 20 °C / Inert atmosphere; Microbiological reaction; Enzymatic reaction

With Dess-Martin periodane; In dichloromethane; acetonitrile;
DOI:10.1002/anie.201907606