GDC-0908

Base Information

Chemical Name:GDC-0908
CAS No.:1282524-10-0
Molecular Formula:C₂₂H₁₇F₂N₅O₂S
Molecular Weight:453.472
Hs Code.:

Synonyms:

Suppliers and Price of GDC-0908

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of GDC-0908

Chemical Property:

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Technology Process of GDC-0908

There total 7 articles about GDC-0908 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114896-64-9
3-thiopheneethanol methanesulfonate (ester)

: 1282524-10-0
GDC-0908

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 2-methyltetrahydrofuran / 24 h / 80 °C / Inert atmosphere

2.1: 2-methyltetrahydrofuran; ethanol / 24 h / 50 °C / 2585.81 Torr / Inert atmosphere

3.1: cesium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

4.1: acetic acid / 0.17 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

5.2: 65 h / 65 °C

6.1: potassium phosphate / water; tetrahydrofuran / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; cesium acetate; palladium diacetate; potassium carbonate; acetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 5.1: |Negishi Coupling;
DOI:10.1021/acs.joc.8b02751

Reference yield:

: methyl 4-bromo-3-(2-(thiophen-3-yl)ethoxy)benzoate

: 1282524-10-0
GDC-0908

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2-methyltetrahydrofuran; ethanol / 24 h / 50 °C / 2585.81 Torr / Inert atmosphere

2.1: cesium acetate; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

3.1: acetic acid / 0.17 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

4.2: 65 h / 65 °C

5.1: potassium phosphate / water; tetrahydrofuran / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; cesium acetate; palladium diacetate; acetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 4.1: |Negishi Coupling;
DOI:10.1021/acs.joc.8b02751

Reference yield:

: N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carboxamide

: 1282524-10-0
GDC-0908

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.17 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 16 h / 65 °C / Inert atmosphere

2.2: 65 h / 65 °C

3.1: potassium phosphate / water; tetrahydrofuran / Inert atmosphere

With potassium phosphate; trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; acetic acid; In tetrahydrofuran; water; 2.1: |Negishi Coupling;
DOI:10.1021/acs.joc.8b02751