C₂₆H₂₇F₃N₆O₃

Base Information

Chemical Name:C₂₆H₂₇F₃N₆O₃
CAS No.:1450666-82-6
Molecular Formula:C₂₆H₂₇F₃N₆O₃
Molecular Weight:528.534
Hs Code.:

C<sub>26</sub>H<sub>27</sub>F<sub>3</sub>N<sub>6</sub>O<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₆H₂₇F₃N₆O₃

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Technology Process of C₂₆H₂₇F₃N₆O₃

There total 5 articles about C₂₆H₂₇F₃N₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.69%

: 1450666-82-6
C₂₆H₂₇F₃N₆O₃

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 1450666-84-8
C₁₁H₈BrN₃O₂

: 1450666-82-6
C₂₆H₂₇F₃N₆O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b01265

Reference yield:

: 1021918-64-8
methyl 4-(5-aminopyrazin-2-yl)benzoate

: 1450666-82-6
C₂₆H₂₇F₃N₆O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; 1,4-dioxane / 16 h / Reflux; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; lithium hydroxide monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 4.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b01265