Technology Process of 2-amino-6-chloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide hydrochloride
There total 7 articles about 2-amino-6-chloro-N-((1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: lithium aluminium tetrahydride / diethyl ether / 12.5 h / Inert atmosphere; Cooling
2: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere
3: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Heating; Inert atmosphere
4: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere
5: water; potassium carbonate / methanol / 16 h / Inert atmosphere; Reflux
6: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere
7: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00914
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere
2: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Heating; Inert atmosphere
3: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere
4: water; potassium carbonate / methanol / 16 h / Inert atmosphere; Reflux
5: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere
6: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00914
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; ammonium formate / methanol / 3 h / Heating; Inert atmosphere
2: triethylamine / dichloromethane / 1 h / 25 °C / Inert atmosphere
3: water; potassium carbonate / methanol / 16 h / Inert atmosphere; Reflux
4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere
5: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b00914
