5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide]

Base Information

• Chemical Name: 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide]
• CAS No.: 858233-01-9
• Molecular Formula: C₂₃H₂₅N₃O₃
• Molecular Weight: 391.47
• Mol file: 858233-01-9.mol

Synonyms:

Chemical Property of 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide]

There total 4 articles about 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-1H-indole-2-carboxylic acid (169463-44-9) → 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide] (858233-01-9)

Guidance literature:

With phosphorus pentachloride; acetyl chloride; Behandeln des Saeurechlorids mit Benzylamino-acetaldehyd-diaethylacetal in CHCl₃;

DOI:10.1021/jo01132a001

Reference yield:

5-Cyano-1H-indole-2-carboxylic acid ethyl ester (105191-13-7) → 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide] (858233-01-9)

Guidance literature:

Multi-step reaction with 2 steps

2: PCl₅; acetyl chloride / Behandeln des Saeurechlorids mit Benzylamino-acetaldehyd-diaethylacetal in CHCl₃

With phosphorus pentachloride; acetyl chloride;

DOI:10.1021/jo01132a001

Reference yield:

3-methyl-4-nitrobenzonitrile (96784-54-2) → 5-cyano-indole-2-carboxylic acid-[benzyl-(2,2-diethoxy-ethyl)-amide] (858233-01-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanolic sodium ethylate

2: zinc-powder; aqueous acetic acid

4: PCl₅; acetyl chloride / Behandeln des Saeurechlorids mit Benzylamino-acetaldehyd-diaethylacetal in CHCl₃

With phosphorus pentachloride; sodium ethanolate; acetic acid; acetyl chloride; zinc;

DOI:10.1021/jo01132a001

upstream raw materials:

5-cyano-1H-indole-2-carboxylic acid

5-Cyano-1H-indole-2-carboxylic acid ethyl ester

3-methyl-4-nitrobenzonitrile

(5-cyano-2-nitro-phenyl)-pyruvic acid ethyl ester