N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid

Base Information

Chemical Name:N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid
CAS No.:1610677-25-2
Molecular Formula:C₂HF₃O₂*C₂₉H₃₀F₂N₆O₃
Molecular Weight:662.616
Hs Code.:

N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid

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Chemical Property of N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid

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Technology Process of N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid

There total 1 articles about N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351374-48-5
N-cyclopropyl-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1610680-14-2
tert-butyl (3-bromo-5-(2,3-difluorophenoxy)pyrazolo[1,5-a]pyrimidin-7-yl)(2-morpholinoethyl)carbamate

: 1610677-25-2
N-cyclopropyl-4-(5-(2,3-difluorophenoxy)-7-((2-morpholinoethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / tetrahydrofuran / 80 - 130 °C / Inert atmosphere; Microwave irradiation

2: dichloromethane

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; 1: |Suzuki Coupling;