Phenylthiodifluor-N,N-diaethylacetamid

Base Information

• Chemical Name: Phenylthiodifluor-N,N-diaethylacetamid
• CAS No.: 24210-62-6
• Molecular Formula: C₁₂H₁₅F₂NOS
• Molecular Weight: 259.32
• Mol file: 24210-62-6.mol

Synonyms:

Chemical Property of Phenylthiodifluor-N,N-diaethylacetamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenylthiodifluor-N,N-diaethylacetamid

There total 5 articles about Phenylthiodifluor-N,N-diaethylacetamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl phenylsulfenylacetate (7605-25-6) → Phenylthiodifluor-N,N-diaethylacetamid (24210-62-6) + α-Fluoro-α-(phenylthio)-N,N-diethylacetamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

1.2: 0.17 h / 0 °C

1.3: 0 - 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 2 h

2.2: pH 1

3.1: thionyl chloride / chloroform

4.1: chloroform / 1 h / 20 °C

5.1: triethylamine tris(hydrogen fluoride) / acetonitrile / 20 °C / Electrochemical reaction; Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; triethylamine tris(hydrogen fluoride); sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; acetonitrile;

DOI:10.3762/bjoc.11.12

Reference yield:

Bis-phenylsulfanyl-acetyl chloride (98834-76-5) → Phenylthiodifluor-N,N-diaethylacetamid (24210-62-6) + α-Fluoro-α-(phenylthio)-N,N-diethylacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 1 h / 20 °C

2: triethylamine tris(hydrogen fluoride) / acetonitrile / 20 °C / Electrochemical reaction; Inert atmosphere

With triethylamine tris(hydrogen fluoride); In chloroform; acetonitrile;

DOI:10.3762/bjoc.11.12

Reference yield:

ethyl α,α-bis(phenylthio)acetate (20461-96-5) → Phenylthiodifluor-N,N-diaethylacetamid (24210-62-6) + α-Fluoro-α-(phenylthio)-N,N-diethylacetamide

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran / 2 h

1.2: pH 1

2.1: thionyl chloride / chloroform

3.1: chloroform / 1 h / 20 °C

4.1: triethylamine tris(hydrogen fluoride) / acetonitrile / 20 °C / Electrochemical reaction; Inert atmosphere

With thionyl chloride; triethylamine tris(hydrogen fluoride); sodium hydroxide; In tetrahydrofuran; chloroform; acetonitrile;

DOI:10.3762/bjoc.11.12

upstream raw materials:

Bisacetic acid

ethyl phenylsulfenylacetate

Bis-phenylsulfanyl-acetyl chloride

ethyl α,α-bis(phenylthio)acetate