Carbamic acid, octadecyl-, 2-(5-methyl-1H-tetrazol-1-yl)-3-(triphenylmethoxy)propyl ester, (S)-

Base Information

• Chemical Name: Carbamic acid, octadecyl-, 2-(5-methyl-1H-tetrazol-1-yl)-3-(triphenylmethoxy)propyl ester, (S)-
• CAS No.: 140712-03-4
• Molecular Formula: C₄₃H₆₁N₅O₃
• Molecular Weight: 695.989
• Mol file: 140712-03-4.mol

Synonyms:

Chemical Property of Carbamic acid, octadecyl-, 2-(5-methyl-1H-tetrazol-1-yl)-3-(triphenylmethoxy)propyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, octadecyl-, 2-(5-methyl-1H-tetrazol-1-yl)-3-(triphenylmethoxy)propyl ester, (S)-

There total 10 articles about Carbamic acid, octadecyl-, 2-(5-methyl-1H-tetrazol-1-yl)-3-(triphenylmethoxy)propyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

octadecyl isocyanate (112-96-9) → Octadecyl-carbamic acid (R)-2-(5-methyl-tetrazol-1-yl)-3-trityloxy-propyl ester (140712-03-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: H⁺ / tetrahydrofuran; methanol

3: Et₃N / CH₂Cl₂

4: PPh₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran

With pyridine; hydrogen cation; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1248/cpb.40.85

Reference yield:

tritylglycerol (16975-62-5,17327-05-8,118014-34-9,18325-46-7) → Octadecyl-carbamic acid 2-(5-methyl-tetrazol-1-yl)-3-trityloxy-propyl ester (140712-03-4)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: 31 percent / PPh₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / Ambient temperature

3: 91 percent / Bu₄NF / tetrahydrofuran

4: pyridine

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.85

Reference yield:

trityl chloride (76-83-5) → Octadecyl-carbamic acid 2-(5-methyl-tetrazol-1-yl)-3-trityloxy-propyl ester (140712-03-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: imidazole / dimethylformamide

3: 31 percent / PPh₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / Ambient temperature

4: 91 percent / Bu₄NF / tetrahydrofuran

5: pyridine

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.40.85

upstream raw materials:

tritylglycerol

trityl chloride

1-dimethyl-tert-butylsilyloxy-3-trityloxypropan-2-ol

1-dimethyl-tert-butylsilyloxy-2-(5-methyl-1H-tetrazol-1-yl)-3-trityloxypropane