benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride

Base Information

• Chemical Name: benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride
• CAS No.: 911367-46-9
• Molecular Formula: C₃₁H₄₃N₅O₇*ClH
• Molecular Weight: 634.173
• Mol file: 911367-46-9.mol

Synonyms:

Chemical Property of benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride

There total 5 articles about benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl-{(4S)-4-amino-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxopentyl}carbamate hydrochloride (911367-44-7) → benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride (911367-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / water; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

benzyl-{2-[{(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}-(2-hydroxyethyl)amino]ethyl}carbamate (911367-43-6) → benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride (911367-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / water; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

benzyl 2-hydroxyethylcarbamate (77987-49-6) → benzyl {(4S)-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxo-4-[(piperidin-3-ylcarbonyl)amino]pentyl}carbamate hydrochloride (911367-46-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: potassium carbonate / acetonitrile / 50 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 15 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / water; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

benzyl-{2-[{(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}-(2-hydroxyethyl)amino]ethyl}carbamate

benzyl-{(4S)-4-amino-5-[(2-{[(benzyloxy)carbonyl]amino}ethyl)(2-hydroxyethyl)amino]-5-oxopentyl}carbamate hydrochloride

benzyl 2-hydroxyethylcarbamate

benzyl-{2-[(2-hydroxyethyl)amino]ethyl}carbamate

Refernces