(3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1,2-diyl)dimethanediyl bis(ethylcarbamate)

Base Information

• Chemical Name: (3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1,2-diyl)dimethanediyl bis(ethylcarbamate)
• CAS No.: 91523-60-3
• Molecular Formula: C₂₁H₂₇N₃O₄
• Molecular Weight: 385.463
• Mol file: 91523-60-3.mol

Synonyms:Pyrrolo[2,1-a]isoquinoline,carbamic acid deriv.; NSC 331133

Chemical Property of (3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1,2-diyl)dimethanediyl bis(ethylcarbamate)

Chemical Property:

• Vapor Pressure: 1.89E-15mmHg at 25°C
• Boiling Point: 623.2°C at 760 mmHg
• Flash Point: 330.7°C
• Density: 1.24g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1,2-diyl)dimethanediyl bis(ethylcarbamate)

There total 2 articles about (3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1,2-diyl)dimethanediyl bis(ethylcarbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1,2-bis(hydroxymethyl)-5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline (91523-57-8) + ethyl isocyanate (109-90-0) → 1,2-bis(hydroxymethyl)-5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline bis(ethylcarbamate) (91523-60-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 26h; Heating;

DOI:10.1021/jm00376a017

Reference yield:

dimethyl 5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate (53927-34-7) → 1,2-bis(hydroxymethyl)-5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline bis(ethylcarbamate) (91523-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Ambient temperature

2: 41 percent / triethylamine / tetrahydrofuran / 26 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jm00376a017

upstream raw materials:

1,2-bis(hydroxymethyl)-5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline

ethyl isocyanate

dimethyl 5,6-dihydro-3-methylpyrrolo<2,1-a>isoquinoline-1,2-dicarboxylate