(R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

Base Information

Chemical Name:(R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine
CAS No.:261165-16-6
Molecular Formula:C₁₄H₁₇F₂NO₄
Molecular Weight:301.29
Hs Code.:

Synonyms:

Suppliers and Price of (R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Activate Scientific
N-Boc-2,5-difluoro-L-phenylalanine 95% ee
1 g
$ 327.00

Activate Scientific
N-Boc-2,5-difluoro-L-phenylalanine 95% ee
5 g
$ 897.00

Acrotein
N-Boc-2,5-difluoro-L-phenylalanine 97%
5g
$ 660.00

Total 6 raw suppliers

Chemical Property of (R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-2,5-difluoro-L-phenylalanine 95% ee ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

There total 1 articles about (R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261380-31-8,261165-16-6
(R)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

Guidance literature:

Reference yield:

: 486460-02-0,261165-16-6
(R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

: 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / 0 °C

1.2: 16 h

2.1: silver benzoate; N-ethyl-N,N-diisopropylamine / methanol / 1.5 h / -30 °C

2.2: Chiralpak AD column / Resolution of racemate

2.3: 4 h / 50 °C

3.1: benzotriazol-1-ol; HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

With silver benzoate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; isobutyl chloroformate; In methanol; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 486460-02-0,261165-16-6
(R,S)-N-(1,1-dimethylethoxycarbonyl)-2,5-difluorophenylalanine

: 7-[(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / 0 °C

1.2: 16 h / 0 °C

2.1: silver benzoate; N-ethyl-N,N-diisopropylamine / 1.5 h / -30 °C

3.1: Resolution of racemate

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 50 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 14 h / 20 °C

6.1: ammonia; water / 6 h / 100 °C

With lithium hydroxide; ammonia; water; silver benzoate; benzotriazol-1-ol; isobutyl chloroformate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); diethyl ether;