methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

Base Information

Chemical Name:methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate
CAS No.:1360821-26-6
Molecular Formula:C₃₀H₂₉Cl₂FN₄O₄
Molecular Weight:599.489
Hs Code.:

methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

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Chemical Property of methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

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Technology Process of methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

There total 7 articles about methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 250789-96-9
methyl 4-{[(tertbutoxycarbonylamino)acetyl]amino}benzoate

: 1360821-26-6
methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

: 1360821-27-7
methyl 4-((2R,3S,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.1: triethylamine / tert-butyl methyl ether / 0.5 h / 20 °C

2.2: 20 °C

3.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

3.2: 20 h / 40 °C

4.1: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel IA, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr

With triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; carbon dioxide;

Reference yield:

: 1000342-80-2
6-chloro-1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one

: 1360821-26-6
methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

: 1360821-27-7
methyl 4-((2R,3S,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine / methanol / 5 h / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 20 h / 40 °C

3.1: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel IA, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr

With piperidine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; carbon dioxide;

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 1360821-26-6
methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

: 1360821-27-7
methyl 4-((2R,3S,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: triethylamine / tert-butyl methyl ether / 0.5 h / 20 °C

3.2: 20 °C

4.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

4.2: 20 h / 40 °C

5.1: Waters/Thar Multi-Gram II, Chiral Technologies, Diacel IA, 3*25 cm / ethanol; carbon dioxide / 35 °C / 75007.5 Torr

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; carbon dioxide;