N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide

Base Information

• Chemical Name: N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide
• CAS No.: 1395050-57-3
• Molecular Formula: C₃₁H₃₈N₈O₃
• Molecular Weight: 570.695
• Mol file: 1395050-57-3.mol

Synonyms:

Chemical Property of N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide

There total 3 articles about N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrophenyl (5-(tert-butyl)isoxazol-3-yl)carbamate (685533-79-3) + N-[3-(4-amino-3-methylphenyl)-1H-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide → N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide (1395050-57-3)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b00106

Reference yield:

3-(3-methyl-4-nitrophenyl)-1H-5-pyrazolamine (1134571-56-4,1433717-99-7) → N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide (1395050-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 °C

2: pyridine / 20 °C

With pyridine;

DOI:10.1021/acs.jmedchem.6b00106

Reference yield:

→ N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]-3-methylphenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide (1395050-57-3)

Guidance literature:

With pyridine; In dimethyl sulfoxide; for 0.5h;

upstream raw materials:

3-(3-methyl-4-nitrophenyl)-1H-5-pyrazolamine

4-nitrophenyl (5-(tert-butyl)isoxazol-3-yl)carbamate