Technology Process of Glycine,
N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl]-L-
cysteinyl]-L-valyl]-L-valyl]-, 2-oxo-2-phenylethyl ester
There total 5 articles about Glycine,
N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl]-L-
cysteinyl]-L-valyl]-L-valyl]-, 2-oxo-2-phenylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dicyclohexylcarbodiimide, triethylamine, 1-hydroxybenzotriazole / tetrahydrofuran / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
2: trifluoroacetic acid-anisole / 1 h / 0 °C
3: triethylamine / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
4: trifluoroacetic acid-anisole / 1 h / 0 °C
5: N-ethyl-N'-dimethylaminopropylcarbodiimide hydrochloride, triethylamine, 1-hydroxybenzotriazole / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
With
trifluoroacetic acid-anisole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1271/bbb.56.108
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
2: trifluoroacetic acid-anisole / 1 h / 0 °C
3: N-ethyl-N'-dimethylaminopropylcarbodiimide hydrochloride, triethylamine, 1-hydroxybenzotriazole / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
With
trifluoroacetic acid-anisole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1271/bbb.56.108
- Guidance literature:
-
Multi-step reaction with 4 steps
1: trifluoroacetic acid-anisole / 1 h / 0 °C
2: triethylamine / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
3: trifluoroacetic acid-anisole / 1 h / 0 °C
4: N-ethyl-N'-dimethylaminopropylcarbodiimide hydrochloride, triethylamine, 1-hydroxybenzotriazole / dimethylformamide / 1.) ice-bath temperature, 1-2 h, 2.) room temperature
With
trifluoroacetic acid-anisole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1271/bbb.56.108
