(1S)-1-(2,6-difluorophenyl)ethan-1-ol

Base Information

Chemical Name:(1S)-1-(2,6-difluorophenyl)ethan-1-ol
CAS No.:126534-38-1
Molecular Formula:C₈H₈F₂O
Molecular Weight:158.148
Hs Code.:
European Community (EC) Number:824-006-5
Nikkaji Number:J2.023.465B

Synonyms:(1S)-1-(2,6-difluorophenyl)ethan-1-ol;126534-38-1;(1S)-1-(2,6-DIFLUOROPHENYL)ETHANOL;(S)-1-(2,6-DIFLUOROPHENYL)ETHAN-1-OL;SCHEMBL20238836;AKOS034825912;AT11387;EN300-56971

Suppliers and Price of (1S)-1-(2,6-difluorophenyl)ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (1S)-1-(2,6-difluorophenyl)ethan-1-ol

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:158.05432120
Heavy Atom Count:11
Complexity:119

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=C(C=CC=C1F)F)O
Isomeric SMILES:C[C@@H](C1=C(C=CC=C1F)F)O

Technology Process of (1S)-1-(2,6-difluorophenyl)ethan-1-ol

There total 9 articles about (1S)-1-(2,6-difluorophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 13670-99-0
2,6-difluoroacetophenone

: 126534-38-1
(S)-1-(2,6-difluorophenyl)ethanol

Guidance literature:: With RuBr₂[(S,S)-2,4-bis-(di-3,5-xylylphosphino)pentane]-2-picolylamine; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 40 ℃; for 21h; under 7600.51 Torr; Autoclave; Inert atmosphere;

Reference yield: 93.0%

: 13670-99-0
2,6-difluoroacetophenone

: 87327-65-9,126534-38-1
2,6-Difluoro-alpha-methylbenzyl alcohol

Guidance literature:: 2,6-difluoroacetophenone; With C₃₉H₄₆ClCuN₂; phenylsilane; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.333333h; Schlenk technique; Inert atmosphere; Glovebox;

With water; sodium hydroxide; In tetrahydrofuran; methanol; for 1h; chemoselective reaction; Schlenk technique; Glovebox;
DOI:10.1021/jo501505j

Reference yield:

: 87327-65-9,126534-38-1
2,6-Difluoro-alpha-methylbenzyl alcohol

: 13670-99-0
2,6-difluoroacetophenone

: 126534-38-1
[R]-1-(2,6-difluorophenyl)-1-ethanol

Guidance literature:: 2,6-Difluoro-alpha-methylbenzyl alcohol; With C₂₈H₃₆ClMnN₂O₂; potassium acetate; In dichloromethane; water; for 0.0833333h;

With N-Bromosuccinimide; In dichloromethane; water; at 20 ℃; for 4h; enantioselective reaction; Kinetics;
DOI:10.1039/c2ob07087a