2-Azetidinone, 1-[(3,4-dimethoxyphenyl)methyl]-3-[1-(methoxymethoxy)ethyl]-4-[2-(phen ylsulfonyl)-2-(2-pyridinylthio)ethyl]-

Base Information

• Chemical Name: 2-Azetidinone, 1-[(3,4-dimethoxyphenyl)methyl]-3-[1-(methoxymethoxy)ethyl]-4-[2-(phen ylsulfonyl)-2-(2-pyridinylthio)ethyl]-
• CAS No.: 140844-33-3
• Molecular Formula: C₂₉H₃₄N₂O₇S₂
• Molecular Weight: 586.73
• Mol file: 140844-33-3.mol

Synonyms:

Chemical Property of 2-Azetidinone, 1-[(3,4-dimethoxyphenyl)methyl]-3-[1-(methoxymethoxy)ethyl]-4-[2-(phen ylsulfonyl)-2-(2-pyridinylthio)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Azetidinone, 1-[(3,4-dimethoxyphenyl)methyl]-3-[1-(methoxymethoxy)ethyl]-4-[2-(phen ylsulfonyl)-2-(2-pyridinylthio)ethyl]-

There total 1 articles about 2-Azetidinone, 1-[(3,4-dimethoxyphenyl)methyl]-3-[1-(methoxymethoxy)ethyl]-4-[2-(phen ylsulfonyl)-2-(2-pyridinylthio)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3S)-1-(3,4-Dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-4-oxo-azetidine-2-carboxylic acid (140844-26-4) → (3S,4R)-4-[2-Benzenesulfonyl-2-(pyridin-2-ylsulfanyl)-ethyl]-1-(3,4-dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one (140844-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) isobutyl chloroformate, N-methyl morpholine / 1) THF, -20 deg C, 30 min, 2) THF, -20 deg C, 45 min

2: tetrahydrofuran / 18 h / Ambient temperature; Irradiation

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)77706-9

Reference yield:

(3S,4R)-4-[2-Benzenesulfonyl-2-(pyridin-2-ylsulfanyl)-ethyl]-1-(3,4-dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one (140844-33-3) → (3S,4S)-4-((E)-2-Benzenesulfonyl-vinyl)-1-(3,4-dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one (140844-43-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1) CHCl₃, 1 h, 2) toluene, reflux, 1 h;

DOI:10.1016/S0040-4039(00)77706-9

upstream raw materials:

(2S,3S)-1-(3,4-Dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-4-oxo-azetidine-2-carboxylic acid

Downstream raw materials:

(3S,4S)-4-((E)-2-Benzenesulfonyl-vinyl)-1-(3,4-dimethoxy-benzyl)-3-((R)-1-methoxymethoxy-ethyl)-azetidin-2-one