C₂₀H₂₀ClN₃O₂

Base Information

• Chemical Name: C₂₀H₂₀ClN₃O₂
• CAS No.: 1424336-61-7
• Molecular Formula: C₂₀H₂₀ClN₃O₂
• Molecular Weight: 369.851
• Mol file: 1424336-61-7.mol

Synonyms:

Chemical Property of C₂₀H₂₀ClN₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀ClN₃O₂

There total 6 articles about C₂₀H₂₀ClN₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (3-oxocyclohexyl)carbamate (320590-29-2) → C20H20ClN3O2 (1424336-61-7) + C20H20ClN3O2 (1424336-60-6)

Guidance literature:

Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; ethyl acetate / -78 °C

1.2: 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 8.5 h / 20 °C / Reflux

3.1: palladium on activated charcoal; hydrogen / methanol / 4 h / 2585.81 Torr

4.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

5.1: lithium hydroxide monohydrate / water; 1,4-dioxane / 5 h / 70 °C

6.1: hydrogenchloride / 1,4-dioxane; ethanol / 100 °C / Microwave irradiation

7.1: isopropyl alcohol; hexane; diethylamine / Resolution of racemate; Irradiation

With hydrogenchloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; diethylamine; isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2012.12.078

Reference yield:

C16H21NO5 (1424336-66-2) → C20H20ClN3O2 (1424336-61-7) + C20H20ClN3O2 (1424336-60-6)

Guidance literature:

Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 8.5 h / 20 °C / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 4 h / 2585.81 Torr

3: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

4: lithium hydroxide monohydrate / water; 1,4-dioxane / 5 h / 70 °C

5: hydrogenchloride / 1,4-dioxane; ethanol / 100 °C / Microwave irradiation

6: isopropyl alcohol; hexane; diethylamine / Resolution of racemate; Irradiation

With hydrogenchloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; diethylamine; isopropyl alcohol; toluene;

DOI:10.1016/j.bmcl.2012.12.078

Reference yield:

C16H20N2O4 (1424336-68-4) → C20H20ClN3O2 (1424336-61-7) + C20H20ClN3O2 (1424336-60-6)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / methanol / 4 h / 2585.81 Torr

2: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane

3: lithium hydroxide monohydrate / water; 1,4-dioxane / 5 h / 70 °C

4: hydrogenchloride / 1,4-dioxane; ethanol / 100 °C / Microwave irradiation

5: isopropyl alcohol; hexane; diethylamine / Resolution of racemate; Irradiation

With hydrogenchloride; lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; diethylamine; isopropyl alcohol;

DOI:10.1016/j.bmcl.2012.12.078

upstream raw materials:

benzyl (3-oxocyclohexyl)carbamate

C₁₆H₂₁NO₅

C₁₆H₂₀N₂O₄

C₁₄H₁₇N₃O₃