C₁₈H₁₅F₂N₃S

Base Information

Chemical Name:C₁₈H₁₅F₂N₃S
CAS No.:1373398-96-9
Molecular Formula:C₁₈H₁₅F₂N₃S
Molecular Weight:343.4
Hs Code.:

C<sub>18</sub>H<sub>15</sub>F<sub>2</sub>N<sub>3</sub>S

Synonyms:

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Chemical Property of C₁₈H₁₅F₂N₃S

Chemical Property:

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Technology Process of C₁₈H₁₅F₂N₃S

There total 6 articles about C₁₈H₁₅F₂N₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21609-70-1
3,4-dihydro-2H-benzo[b]thiepin-5-one

: 1373398-95-8
C₁₈H₁₅F₂N₃S

: 1373398-96-9
C₁₈H₁₅F₂N₃S

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - 0 °C / Inert atmosphere

1.2: 0.7 h / -78 - 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / 0 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

5.1: cesium fluoride / [D₃]acetonitrile / 1 h / 20 °C

6.1: [D₃]acetonitrile / 0.33 h / 20 °C

With trimethylaluminum; sodium hexamethyldisilazane; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; [D₃]acetonitrile; ethylbenzene; toluene;
DOI:10.1002/anie.201106325

Reference yield:

: 1373398-87-8
4-fluoro-3,4-dihydrobenzo[b]thiepin-5(2H)-one

: 1373398-95-8
C₁₈H₁₅F₂N₃S

: 1373398-96-9
C₁₈H₁₅F₂N₃S

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / 0 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: cesium fluoride / [D₃]acetonitrile / 1 h / 20 °C

5.1: [D₃]acetonitrile / 0.33 h / 20 °C

With trimethylaluminum; sodium hexamethyldisilazane; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; [D₃]acetonitrile; ethylbenzene; toluene;
DOI:10.1002/anie.201106325

Reference yield:

: 1373398-85-6
4,4-difluoro-3,4-dihydrobenzo[b]thiepin-5(2H)-one

: 1373398-95-8
C₁₈H₁₅F₂N₃S

: 1373398-96-9
C₁₈H₁₅F₂N₃S

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylaluminum / dichloromethane; toluene / 0.17 h / 0 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: cesium fluoride / [D₃]acetonitrile / 1 h / 20 °C

4.1: [D₃]acetonitrile / 0.33 h / 20 °C

With trimethylaluminum; sodium hexamethyldisilazane; cesium fluoride; In tetrahydrofuran; dichloromethane; [D₃]acetonitrile; toluene;
DOI:10.1002/anie.201106325