rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

Base Information

Chemical Name:rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone
CAS No.:1143519-25-8
Molecular Formula:C₃₇H₄₇Cl₂N₅O₄S
Molecular Weight:728.783
Hs Code.:

rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

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Chemical Property of rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

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Technology Process of rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

There total 9 articles about rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1143519-20-3
6-tert-butyl-4-ethoxy-nicotinic acid ethyl ester

: rac-[(4R,5S)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

: 1143519-25-8
rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; water / ethanol / 1 h / 80 °C

2.1: thionyl chloride / 2 h / 70 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.83 h / -10 °C

4.1: trichlorophosphate / toluene / Heating / reflux

4.2: 0 °C

5.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

6.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

7.1: Resolution of racemate

With potassium hydroxide; thionyl chloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: rac-5-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl]-2-tert-butyl-4-ethoxypyridine

: rac-[(4R,5S)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

: 1143519-25-8
rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: Resolution of racemate

With triethylamine; In dichloromethane; toluene;

Reference yield:

: rac-N-[(1R,2S)-2-amino-1,2-bis(4-chlorophenyl)-1-methylpropyl]-6-tert-butyl-4-ethoxynicotinamide

: rac-[(4R,5S)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

: 1143519-25-8
rac-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methanesulfonyl-propyl)-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / toluene / Heating / reflux

1.2: 0 °C

2.1: triethylamine / dichloromethane; toluene / 0.5 h / 0 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: Resolution of racemate

With triethylamine; trichlorophosphate; In dichloromethane; toluene;