1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole

Base Information

• Chemical Name: 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole
• CAS No.: 1444309-28-7
• Molecular Formula: C₁₅H₁₅N₅O₂
• Molecular Weight: 297.316
• Mol file: 1444309-28-7.mol

Synonyms:

Chemical Property of 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole

There total 4 articles about 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-methoxy-1,1,1-trichloro-pent-3-en-2-one → 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole (1444309-28-7) + 1-[1H-pyrazole-3-yl-5-carboxyethyl ester]-methyl-5-phenyl-1,2,3-triazole (1444309-30-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / acetone / 25 °C

2: hydrazine / ethanol / 24 h / 65 °C

3: toluene / 24 h / 110 °C

With sodium azide; hydrazine; In ethanol; acetone; toluene;

DOI:10.1002/jhet.996

Reference yield:

C6H6Cl3N3O2 (401512-55-8) → 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole (1444309-28-7) + 1-[1H-pyrazole-3-yl-5-carboxyethyl ester]-methyl-5-phenyl-1,2,3-triazole (1444309-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethanol / 24 h / 65 °C

2: toluene / 24 h / 110 °C

With hydrazine; In ethanol; toluene;

DOI:10.1002/jhet.996

Reference yield:

1,1,1-trichloro-4-methoxy-3-penten-2-one (135351-18-7,83124-77-0) → 1-[1H-pyrazol-3-yl-5-carboxyethyl ester]-methyl-4-phenyl-1,2,3-triazole (1444309-28-7) + 1-[1H-pyrazole-3-yl-5-carboxyethyl ester]-methyl-5-phenyl-1,2,3-triazole (1444309-30-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / dichloromethane / 1 h / 25 °C

1.2: 1 h / 0 °C

2.1: sodium azide / acetone / 25 °C

3.1: hydrazine / ethanol / 24 h / 65 °C

4.1: toluene / 24 h / 110 °C

With sodium azide; bromine; hydrazine; In ethanol; dichloromethane; acetone; toluene;

DOI:10.1002/jhet.996

upstream raw materials:

C₆H₆Cl₃N₃O₂

3-azidomethyl-1H-pyrazole-5-carboxyethyl ester

phenylacetylene

1,1,1-trichloro-4-methoxy-3-penten-2-one