Technology Process of N-(2,4-dichlorophenyl)-5-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-2-furamide
There total 6 articles about N-(2,4-dichlorophenyl)-5-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-2-furamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetonitrile / 8 h / 60 °C
2.1: sodium hydroxide / methanol / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.33 h / 0 °C
3.2: 12 h / 20 °C
With
potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.0c02018
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 10 h / 0 - 20 °C
2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
3.1: sodium iodide / acetone / 10 h / Reflux
4.1: potassium carbonate / acetonitrile / 8 h / 60 °C
5.1: sodium hydroxide / methanol / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.33 h / 0 °C
6.2: 12 h / 20 °C
With
thionyl chloride; sulfuric acid; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; sodium hydroxide;
In
methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/acs.jmedchem.0c02018
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
2.1: sodium iodide / acetone / 10 h / Reflux
3.1: potassium carbonate / acetonitrile / 8 h / 60 °C
4.1: sodium hydroxide / methanol / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.33 h / 0 °C
5.2: 12 h / 20 °C
With
thionyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium iodide; sodium hydroxide;
In
methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/acs.jmedchem.0c02018