(S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid
• CAS No.: 117710-25-5
• Molecular Formula: C₂HF₃O₂*C₃₁H₃₉N₃O₈
• Molecular Weight: 695.69
• Mol file: 117710-25-5.mol

Synonyms:

Chemical Property of (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid

There total 4 articles about (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid (117710-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / N,N-dicyclohexylcarbodiimide (DCC) / 24 h / 0 °C

2: 0.5 h

With dicyclohexyl-carbodiimide;

DOI:10.1021/jo00264a022

Reference yield:

symmetric anhydride of Boc-Pro-OH (33294-56-3) → (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid (117710-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 0.08 h / 130 °C

2: 0.5 h

DOI:10.1021/jo00264a022

Reference yield:

(S)-2-Benzyloxycarbonylamino-3-[(S)-3-(4-methoxy-phenyl)-2-methylamino-propionyloxy]-butyric acid allyl ester (117710-22-2) → (S)-2-Benzyloxycarbonylamino-3-{(S)-3-(4-methoxy-phenyl)-2-[methyl-((S)-pyrrolidine-2-carbonyl)-amino]-propionyloxy}-butyric acid allyl ester; compound with trifluoro-acetic acid (117710-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 0.08 h / 130 °C

2: 0.5 h

DOI:10.1021/jo00264a022

upstream raw materials:

allyl N-(benzyloxycarbonyl)-O-<-(N,O-dimethyl-L-tyrosyl)>-L-threoninate

trifluoroacetic acid

1-(tert-butoxycarbonyl)-L-proline

symmetric anhydride of Boc-Pro-OH