Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

Base Information

Chemical Name:Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-
CAS No.:140896-68-0
Molecular Formula:C40H46N5O7PSi
Molecular Weight:767.894
Hs Code.:

Phosphonic acid,
[4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1,
1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl)
ester, (E)-

Synonyms:

Suppliers and Price of Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

Chemical Property:

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Technology Process of Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

There total 7 articles about Phosphonic acid, [4-[[6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-9H-purin-9-yl]oxy]-3-[[[(1, 1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 124077-13-0
9-hydroxy-6-N-phthalimidopurine

: 148120-72-3
diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate

: 140896-68-0
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>-6-N-phthalimidopurine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/jm00062a006

Reference yield: 62.0%

: 140896-68-0
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>-6-N-phthalimidopurine

Guidance literature:

Reference yield:

: 1660-95-3
Tetraisopropyl methylenediphosphonate

: 140896-68-0
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>-6-N-phthalimidopurine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-butyllithium / 1.) n-hexane, n-heptane, RT, 15 min, 2.) n-hexane, n-heptane, RT, 15 min

2: 63 percent / HCl / methanol / 1.5 h / Ambient temperature

3: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 2 h / Ambient temperature

4: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature

5: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature

6: 62 percent / PPh₃, DEAD / tetrahydrofuran / 18 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; methanol; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm00062a006