4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

Base Information

Chemical Name:4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid
CAS No.:943741-75-1
Molecular Formula:C₂₇H₃₉BN₂O₈S
Molecular Weight:562.492
Hs Code.:

4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

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Chemical Property of 4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

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Technology Process of 4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

There total 5 articles about 4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 943741-75-1
4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

Guidance literature:

Reference yield:

: 175278-30-5
1-iodo-2-ethyl-4-bromobenzene

: 943741-75-1
4-(2-(3-((tert-butoxycarbonyl(methyl)amino)methyl)-4-(isopropylsulfonyl)phenylcarbamoyloxy)ethyl)-3-ethylphenylboronic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tetrabutyl-ammonium chloride / toluene / 0.75 h / 170 °C / Molecular sieve

2: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 120 °C

3: sodium hydride / tetrahydrofuran / 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 4 h / 80 °C

5: trifluoroacetic acid; water / methanol

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tetrabutyl-ammonium chloride; water; potassium acetate; sodium hydride; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene; 4: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.04.008