(2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one

Base Information

• Chemical Name: (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one
• CAS No.: 1415730-34-5
• Molecular Formula: C₃₄H₅₈O₇Si
• Molecular Weight: 606.916

Synonyms:

Chemical Property of (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one

There total 17 articles about (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[[3-(2S,3R,4S,5R)-4S]-3-(5-(tert-butyldimethylsilyloxy)-3-hydroxy-2,4,6-trimethyl-1-oxohept-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone (1415730-32-3) → (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-34-5) + (2S,4S,7R,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-28-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridine; pyridine hydrogenfluoride; water / tetrahydrofuran / 120 h / 20 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: lithium borohydride; ethanol / diethyl ether / 4 h / -10 °C / Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 - 0 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: 5 h / -78 °C / Inert atmosphere

With pyridine; lithium borohydride; oxalyl dichloride; ethanol; water; pyridinium p-toluenesulfonate; pyridine hydrogenfluoride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2012.10.008

Reference yield:

(3S)-4-((4-methoxybenzyl)oxy)-3-methylbutanal → (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-34-5) + (2S,4S,7R,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-28-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: phthalic acid dimethyl ester; water / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethyl sulfide borane / tetrahydrofuran; toluene / 2 h / -30 °C / Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 7.5 h / -78 °C / Inert atmosphere

5.1: pyridinium p-toluenesulfonate; mercury(II) diacetate / tetrahydrofuran / 5 h / 45 °C / pH 7 / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.2: 5 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; phthalic acid dimethyl ester; mercury(II) diacetate; water; dimethyl sulfide borane; pyridinium p-toluenesulfonate; lithium hexamethyldisilazane; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; toluene; 1.1: |Grignard Reaction;

DOI:10.1016/j.tet.2012.10.008

Reference yield:

(2S,3R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylpent-4-en-1-ol (1415730-47-0) → (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-34-5) + (2S,4S,7R,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one (1415730-28-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 0 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

2.3: 4.5 h / -78 - 0 °C / Inert atmosphere

3.1: pyridine; pyridine hydrogenfluoride; water / tetrahydrofuran / 120 h / 20 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: lithium borohydride; ethanol / diethyl ether / 4 h / -10 °C / Inert atmosphere

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

6.2: 1 h / -78 - 0 °C / Inert atmosphere

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.2: 5 h / -78 °C / Inert atmosphere

With pyridine; lithium borohydride; oxalyl dichloride; ethanol; di-n-butylboryl trifluoromethanesulfonate; water; pyridinium p-toluenesulfonate; pyridine hydrogenfluoride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2012.10.008

upstream raw materials:

(2S,3R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylpent-4-en-1-ol

(5S)-6-(4-methoxybenzyl)oxy-5-methyl-3-oxohex-1-yne

(3S,5S)-3-(tert-butyldimethylsilyloxy)-6-((4-methoxybenzyl)oxy)-5-methylhex-1-yne

[[3-(2S,3R,4S,5R)-4S]-3-(5-(tert-butyldimethylsilyloxy)-3-hydroxy-2,4,6-trimethyl-1-oxohept-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1415730-34-5 (2S,4S,7S,8R,9S,10S,11R)-4-(tert-butyldimethylsilyloxy)-1-((4-methoxyphenyl)oxy)-7-hydroxy-2,8,10,12-tetramethyl-9,11-[(bis-dimethylmethylene)dioxy]-tridec-12-en-5-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send