Technology Process of (S)-2-amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid
There total 10 articles about (S)-2-amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate; sulfuric acid / diethyl ether; diethylene glycol dimethyl ether / 20 - 75 °C
2.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 20 °C
4.1: montmorillonite KSF clay / dichloromethane / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / Reflux
5.2: Reflux
6.1: palladium 10% on activated carbon; ammonium formate / methanol / 80 °C
7.1: triethylamine; trifluoroacetic acid / ethanol; n-heptane / Resolution of racemate
With
hydrogenchloride; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; dihydrogen peroxide; ammonium formate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
1,4-dioxane; methanol; diethyl ether; ethanol; n-heptane; dichloromethane; diethylene glycol dimethyl ether; water;
4.1: Strecker synthesis;
DOI:10.1021/jm201195m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C
2.1: Dess-Martin periodane / dichloromethane / 20 °C
3.1: montmorillonite KSF clay / dichloromethane / 20 °C
4.1: hydrogenchloride / 1,4-dioxane / Reflux
4.2: Reflux
5.1: palladium 10% on activated carbon; ammonium formate / methanol / 80 °C
6.1: triethylamine; trifluoroacetic acid / ethanol; n-heptane / Resolution of racemate
With
hydrogenchloride; palladium 10% on activated carbon; dihydrogen peroxide; ammonium formate; Dess-Martin periodane; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; water;
3.1: Strecker synthesis;
DOI:10.1021/jm201195m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Dess-Martin periodane / dichloromethane / 20 °C
2.1: montmorillonite KSF clay / dichloromethane / 20 °C
3.1: hydrogenchloride / 1,4-dioxane / Reflux
3.2: Reflux
4.1: palladium 10% on activated carbon; ammonium formate / methanol / 80 °C
5.1: triethylamine; trifluoroacetic acid / ethanol; n-heptane / Resolution of racemate
With
hydrogenchloride; palladium 10% on activated carbon; ammonium formate; Dess-Martin periodane; triethylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane;
2.1: Strecker synthesis;
DOI:10.1021/jm201195m
