(2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide

Base Information

• Chemical Name: (2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide
• CAS No.: 1403684-13-8
• Molecular Formula: C₁₉H₁₈BrN₃O₃S
• Molecular Weight: 448.34
• Mol file: 1403684-13-8.mol

Synonyms:

Chemical Property of (2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide

There total 1 articles about (2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorobenzo[d][1,3]thiazole (615-20-3) → (2S,3R)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide (1403684-13-8) + (2R,3S)-2-(1,3-benzothiazol-2-yl)-3-(4-bromophenyl)-N,N-dimethyl-4-nitrobutanamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / toluene / 23 h / 0 - 20 °C

2.1: C₄₀H₄₈Br₂N₄Ni / 1,4-dioxane / 0.08 h / 20 °C / Molecular sieve

2.2: 18 h / 20 °C / Molecular sieve

With C₄₀H₄₈Br₂N₄Ni; sodium hexamethyldisilazane; In 1,4-dioxane; toluene; 2.2: |Michael Addition;

DOI:10.1002/chem.201202093

upstream raw materials:

2-chlorobenzo[d][1,3]thiazole