3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE

Base Information

• Chemical Name: 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE
• CAS No.: 1849-49-6
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 1849-49-6.mol

Synonyms:Isonicotinaldehyde,3-hydroxy-2,5-dimethyl- (6CI,7CI,8CI); 2,5-Dimethyl-4-formyl-3-hydroxypyridine;5-Deoxypyridoxal; 5-Desoxypyridoxal; 5'-Deoxypyridoxal

Chemical Property of 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000188mmHg at 25°C
• Boiling Point: 318.9 °C at 760 mmHg
• Flash Point: 146.7 °C
• PSA: 50.19000
• Density: 1.206 g/cm³
• LogP: 1.21650
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydroxy-2,5-dimethylisonicotinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE

There total 12 articles about 3-HYDROXY-2,5-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.1%

5'-Deoxypyridoxine (4811-03-4) → 5'-deoxypyridoxal (1849-49-6)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 20h; Inert atmosphere;

Reference yield:

4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol (143571-93-1) → 5'-deoxypyridoxal (1849-49-6) + hexan-1-amine (111-26-2)

Guidance literature:

With water; In 1,4-dioxane; at 25 ℃; Rate constant; var. solvents;

Reference yield:

4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol (128669-12-5) → 5'-deoxypyridoxal (1849-49-6) + hexan-1-amine (111-26-2)

Guidance literature:

With ethylene glycol; at 25 ℃; Rate constant; other reagent;

upstream raw materials:

5'-Deoxypyridoxine

4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol

4-[(E)-Hexyliminomethyl]-2,5-dimethyl-pyridin-3-ol

2-amino-3-(carboxymethyl-amino)-3-(3-hydroxy-2,5-dimethyl-pyridin-4-yl)-propionic acid

Downstream raw materials:

5,8-Dimethyl-3-phenyl-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazine

2,5-Dimethyl-4-phenylaminomethyl-pyridin-3-ol

Refernces

• 1、 Toth, Krisztina,Gaskell, Lauren M.,Richard, John P.. "Claisen-type addition of glycine to a pyridoxal iminium ion in water". . p. 7094 - 7096. Retrieved 2007/10/03.
• 2、 Vazquez, Miguel A.,Donosa, Josefa,Munoz, Francisco,Blanco, Francisco Garcia,Vado, M. Angeles Garcia del,Echevarria, Gerardo. "Formation of Schiff Bases of 5'-Deoxypyridoxal and Hexylamine in Aqueous and Non-aqueous Media". . p. 1143 - 1147. Retrieved 2007/10/02.