2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride

Base Information

• Chemical Name: 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride
• CAS No.: 73790-21-3
• Molecular Formula: C₈H₇F₄N*ClH
• Molecular Weight: 229.605
• Mol file: 73790-21-3.mol

Synonyms:

Chemical Property of 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride

There total 4 articles about 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α,α,3,4-tetrafluorobenzeneacetamide (73790-15-5) → 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride (73790-21-3)

Guidance literature:

With hydrogenchloride; methanol; dimethylsulfide borane complex; Yield given. Multistep reaction; 1) overnight RT, 2h reflux, 2) overnight RT, 0.5h reflux;

DOI:10.1021/jo01302a025

Reference yield:

1-bromo-3,4-difluorobenzene (348-61-8) → 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride (73790-21-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) Mg / diethyl ether, 1) reflux, 2) -50 deg C

2: 65 percent / (diethylamino)sulfur trifluoride

3: 83 percent / NH₃ / 25 °C

4: 1)borane methyl sulfide, 2) methanol, HCl / 1) overnight RT, 2h reflux, 2) overnight RT, 0.5h reflux

With hydrogenchloride; methanol; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; ammonia; magnesium;

DOI:10.1021/jo01302a025

Reference yield:

ethyl 3,4-difluoro-α-oxobenzeneacetate (73790-05-3) → 2,2-difluoro-2-(3,4-difluorophenyl)ethylamine hydrochloride (73790-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / (diethylamino)sulfur trifluoride

2: 83 percent / NH₃ / 25 °C

3: 1)borane methyl sulfide, 2) methanol, HCl / 1) overnight RT, 2h reflux, 2) overnight RT, 0.5h reflux

With hydrogenchloride; methanol; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; ammonia;

DOI:10.1021/jo01302a025

upstream raw materials:

α,α,3,4-tetrafluorobenzeneacetamide

1-bromo-3,4-difluorobenzene

ethyl 3,4-difluoro-α-oxobenzeneacetate

ethyl α,α,3,4-tetrafluorobenzeneacetate