racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Base Information

Chemical Name:racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
CAS No.:1239779-16-8
Molecular Formula:C₂₉H₂₇Cl₂FN₄O₆S
Molecular Weight:649.527
Hs Code.:

racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

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Chemical Property of racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Chemical Property:

Purity/Quality:

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Hazard Codes:

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Technology Process of racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

There total 6 articles about racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: racemic (2'S,3S,4'R)-6-chloro-4'-[5-chloro-2-(1-hydroxycarbonyl-1-methyl-ethoxy)pyridin-3-yl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

: 1239779-17-9
racemic (2'R,3R,4'S)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

: 1239779-16-8
racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 60 °C

1.2: 3 h / 20 °C

1.3: pH 1 - 2

2.1: Resolution of racemate; chiral SFC

With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

Reference yield:

: C₃₄H₃₄Cl₂FN₃O₇

: 1239779-17-9
racemic (2'R,3R,4'S)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

: 1239779-16-8
racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.1: lithium hydroxide monohydrate; water / methanol / 0.67 h / 80 °C

2.2: 20 °C / pH 1

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 60 °C

3.2: 3 h / 20 °C

3.3: pH 1 - 2

4.1: Resolution of racemate; chiral SFC

With lithium hydroxide monohydrate; water; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 22062-53-9
5-fluoro-2-methylbenzaldehyde

: 1239779-17-9
racemic (2'R,3R,4'S)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

: 1239779-16-8
racemic (2'S,3S,4'R)-4'-[5-chloro-2-(2-methanesulfonylamino-1,1-methyl-2-oxo-ethoxy)pyridin-3-yl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: toluene / 2 h / 130 °C

3.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

4.1: lithium hydroxide monohydrate; water / methanol / 0.67 h / 80 °C

4.2: 20 °C / pH 1

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 60 °C

5.2: 3 h / 20 °C

5.3: pH 1 - 2

6.1: Resolution of racemate; chiral SFC

With n-butyllithium; lithium hydroxide monohydrate; water; 1,1,1,3,3,3-hexamethyl-disilazane; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;