methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate

Base Information

• Chemical Name: methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate
• CAS No.: 1113007-46-7
• Molecular Formula: C₂₉H₃₃N₃O₆S
• Molecular Weight: 551.664
• Mol file: 1113007-46-7.mol

Synonyms:

Chemical Property of methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate

There total 1 articles about methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl ester hydrochloride (1113007-56-9) + methyl (L)-leucinate hydrochloride (7517-19-3) + 1H-imidazole-1-carbodithioic acid methyl ester (74734-11-5) → methyl (αS,5S,11aR)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate (1113007-46-7) + methyl (αR,5R,11aS)-α-isobutyl-1-oxo-3-thioxo-5-(3,4,5-trimethoxyphenyl)-1,2,3,5,11,11a-hexahydro-2(6H)-imidazo-[1,5-b]-β-carbolineacetate

Guidance literature:

methyl (L)-leucinate hydrochloride; 1H-imidazole-1-carbodithioic acid methyl ester; With triethylamine; In methanol; for 1h; Reflux;

cis-1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl ester hydrochloride; With triethylamine; In methanol; optical yield given as %ee; Reflux;

DOI:10.1016/j.tetlet.2008.11.008

upstream raw materials:

cis-1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid methyl ester hydrochloride

methyl (L)-leucinate hydrochloride

1H-imidazole-1-carbodithioic acid methyl ester