8H-Quinazolino[4,3-b]quinazoline, 8-[(2-chlorophenyl)methylene]-

Base Information

• Chemical Name: 8H-Quinazolino[4,3-b]quinazoline, 8-[(2-chlorophenyl)methylene]-
• CAS No.: 141034-53-9
• Molecular Formula: C₂₂H₁₄ClN₃
• Molecular Weight: 355.826
• Mol file: 141034-53-9.mol

Synonyms:

Chemical Property of 8H-Quinazolino[4,3-b]quinazoline, 8-[(2-chlorophenyl)methylene]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8H-Quinazolino[4,3-b]quinazoline, 8-[(2-chlorophenyl)methylene]-

There total 10 articles about 8H-Quinazolino[4,3-b]quinazoline, 8-[(2-chlorophenyl)methylene]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(2-aminophenyl)-4-(2-chlorobenzyl)quinazoline (141034-51-7) + orthoformic acid triethyl ester (122-51-0) → 7-(2-chlorobenzylidene)-7H-5,6a,12-triazabenzanthracene (141034-53-9)

Guidance literature:

for 4h; Heating;

Reference yield:

3-(2-chlorobenzyl)-2-methylindole (7791-54-0) → 7-(2-chlorobenzylidene)-7H-5,6a,12-triazabenzanthracene (141034-53-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) O₃, 2.) Zn dust / 1.) AcOH, 2.) AcOH, overnight

2: 74 percent / aq. HCl / ethanol / 3 h / Heating

3: 1.) HCl, 2.) aq. NH₃ / 1.) acetone, reflux, 1.5 h, 2.) EtOH, H₂O, reflux, 15 min

4: 89 percent / aq. NaOH / ethanol / 1.5 h / Heating

5: 91 percent / 4 h / Heating

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; ozone; zinc; In ethanol;

Reference yield:

2-chlorobenzalacetone (91574-67-3,91574-68-4,20766-37-4) → 7-(2-chlorobenzylidene)-7H-5,6a,12-triazabenzanthracene (141034-53-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 70 percent / H₂ / platinum oxide / ethyl acetate / 1.2 h / 760 Torr

2: 2.) ZnCl₂ / 1.) 100 deg C, 0.5 h, 2.) 170 deg C, 15 min

3: 1.) O₃, 2.) Zn dust / 1.) AcOH, 2.) AcOH, overnight

4: 74 percent / aq. HCl / ethanol / 3 h / Heating

5: 1.) HCl, 2.) aq. NH₃ / 1.) acetone, reflux, 1.5 h, 2.) EtOH, H₂O, reflux, 15 min

6: 89 percent / aq. NaOH / ethanol / 1.5 h / Heating

7: 91 percent / 4 h / Heating

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; hydrogen; ozone; zinc(II) chloride; zinc; platinum(IV) oxide; In ethanol; ethyl acetate;

upstream raw materials:

2-(2-aminophenyl)-4-(2-chlorobenzyl)quinazoline

orthoformic acid triethyl ester

3-(2-chlorobenzyl)-2-methylindole

2-chlorobenzalacetone