2-Hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde
• CAS No.: 141074-39-7
• Molecular Formula: C₁₃H₁₈O₆
• Molecular Weight: 270.282
• DSSTox Substance ID: DTXSID20579804
• Wikidata: Q82470428
• Mol file: 141074-39-7.mol

Synonyms:141074-39-7;2-hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde;2-HYDROXY-3-{2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHOXY}BENZALDEHYDE;DTXSID20579804

Chemical Property of 2-Hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde

Chemical Property:

• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 270.11033829
• Heavy Atom Count: 19
• Complexity: 235

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)OCCOCCOCCO)O)C=O

Technology Process of 2-Hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde

There total 2 articles about 2-Hydroxy-3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → 2-hydroxy-3-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>benzaldehyde (141074-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NEt₃ / CH₂Cl₂ / 1) 3h, RT, 2) 1h, reflux

2: 1) NaH / 1) DMSO, 20 to 25 deg C, 1h, 2) DMSO, 20 to 25 deg C, 24h

With sodium hydride; triethylamine; In dichloromethane;

Reference yield:

2,3-dihydroxybenzaldehyde (24677-78-9) + 8-tosyloxy-3,6-dioxaoctanol (77544-68-4) → 2-hydroxy-3-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>benzaldehyde (141074-39-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMSO, 20 to 25 deg C, 1h, 2) DMSO, 20 to 25 deg C, 24h;

Reference yield:

2-hydroxy-3-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>benzaldehyde (141074-39-7) → 3,3'-disalicylaldehyde (141074-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / benzene / 3 h / Heating

2: 82 percent / NaH / tetrahydrofuran / 3 h / Heating

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

upstream raw materials:

2,3-dihydroxybenzaldehyde

8-tosyloxy-3,6-dioxaoctanol

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

6-(1,3-dioxolan-2-yl)-2-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>phenol

3,3'-disalicylaldehyde

3,3'-<2,6-pyridinediylbis(methyleneoxyethyleneoxyethyleneoxyethyleneoxy)>disalicylaldehyde

3,3'-<2,5-furandiylbis(methyleneoxyethyleneoxyethyleneoxyethyleneoxy)>disalicylaldehyde