1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro-

Base Information

Chemical Name:1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro-
CAS No.:141106-48-1
Molecular Formula:C23H30FNO
Molecular Weight:355.496
Hs Code.:

Synonyms:

Suppliers and Price of 1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro-

Chemical Property:

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Technology Process of 1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro-

There total 13 articles about 1-Benzoxepin-5-amine, 8-(4-fluorophenyl)-N-heptyl-2,3,4,5-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10540-41-7
4'-fluoro-[1,1'-biphenyl]-3-ol

: 141106-48-1
(+/-)-N-8-(4-fluorophenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-yl-N₁-n-heptylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOH / 1.) EtOH, reflux, 1 h, 2.) 190 deg C, 4 h

2: 78 percent / polyphosphoric acid / xylene / 4 h / Heating

3: 1.) p-toluenesulfonic acid, 2.) NaBH₄ / 1.) xylene, reflux, 14 h, 2.) EtOH, H₂O, RT, 12 h

With sodium hydroxide; sodium tetrahydroborate; PPA; toluene-4-sulfonic acid; In xylene;
DOI:10.1016/0223-5234(96)88247-X

Reference yield:

: 141106-45-8
4-<3-(4-fluorophenyl)phenoxy>butanoic acid

: 141106-48-1
(+/-)-N-8-(4-fluorophenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-yl-N₁-n-heptylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / polyphosphoric acid / xylene / 4 h / Heating

2: 1.) p-toluenesulfonic acid, 2.) NaBH₄ / 1.) xylene, reflux, 14 h, 2.) EtOH, H₂O, RT, 12 h

With sodium tetrahydroborate; PPA; toluene-4-sulfonic acid; In xylene;
DOI:10.1016/0223-5234(96)88247-X

Reference yield:

: 873784-26-0
methyl 4-(4′-fluorophenyl)-2-hydroxybenzoate

: 141106-48-1
(+/-)-N-8-(4-fluorophenyl)-2,3,4,5-tetrahydro-1-benzoxepin-5-yl-N₁-n-heptylamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

3.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 20 °C

5.1: diisobutylaluminium hydride / hexane; dichloromethane

6.1: dichloromethane / 1 h

6.2: 1.5 h / 20 °C

7.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 - 20 °C

7.2: 2.5 h / -10 - 20 °C

8.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 50 °C

9.1: hydrogen; palladium on activated carbon / ethyl acetate / 3 h / Saturated gas

10.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium aluminium tetrahydride; palladium on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.6b01691