(1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid

Base Information

• Chemical Name: (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid
• CAS No.: 102022-65-1
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 102022-65-1.mol

Synonyms:

Chemical Property of (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid

There total 4 articles about (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyano-3-(1-methyl-2-phenyl-indol-3-yl)-acrylic acid ethyl ester (102311-49-9) → (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid (102022-65-1)

Guidance literature:

With strontium(II) carbonate; palladium on activated charcoal; ethanol; Hydrogenation_.Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH;

Reference yield:

2-phenyl-indole (948-65-2) → (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid (102022-65-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium amide; liquid ammonia / und anschliessend mit Methyljodid

2: phosphoryl chloride / 35 °C / Behandeln des erhaltenen Reaktionsgemisches mit Wasser

3: pyridine; isopropyl alcohol; piperidine

4: palladium/charcoal /SrCO₃-catalyst; ethanol / Hydrogenation_.Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH

With piperidine; pyridine; strontium(II) carbonate; palladium on activated charcoal; ethanol; ammonia; sodium amide; isopropyl alcohol; trichlorophosphate;

Reference yield:

1-methyl-2-phenyl-1H-indole (3558-24-5) → (1-methyl-2-phenyl-indol-3-ylmethyl)-malonic acid (102022-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphoryl chloride / 35 °C / Behandeln des erhaltenen Reaktionsgemisches mit Wasser

2: pyridine; isopropyl alcohol; piperidine

3: palladium/charcoal /SrCO₃-catalyst; ethanol / Hydrogenation_.Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH

With piperidine; pyridine; strontium(II) carbonate; palladium on activated charcoal; ethanol; isopropyl alcohol; trichlorophosphate;

upstream raw materials:

2-cyano-3-(1-methyl-2-phenyl-indol-3-yl)-acrylic acid ethyl ester

2-phenyl-indole

1-methyl-2-phenyl-1H-indole

1-methyl-2-phenyl-1H-indole-3-carbaldehyde