1(2H)-Phthalazinone, 4-(4-chloro-3-methylphenyl)-, hydrazone

Base Information

• Chemical Name: 1(2H)-Phthalazinone, 4-(4-chloro-3-methylphenyl)-, hydrazone
• CAS No.: 141123-38-8
• Molecular Formula: C15H13ClN4
• Molecular Weight: 284.748
• Mol file: 141123-38-8.mol

Synonyms:

Chemical Property of 1(2H)-Phthalazinone, 4-(4-chloro-3-methylphenyl)-, hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(2H)-Phthalazinone, 4-(4-chloro-3-methylphenyl)-, hydrazone

There total 5 articles about 1(2H)-Phthalazinone, 4-(4-chloro-3-methylphenyl)-, hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-chloro-4-(4-chloro-3-methyl-phenyl)-phthalazine (141123-37-7) → [4-(4-chloro-3-methyl-phenyl)-phthalazin-1-yl]-hydrazine (141123-38-8)

Guidance literature:

With hydrazine hydrate; In benzene; for 6h; Heating;

Reference yield:

4-(4'-chloro-3'-methylphenyl)-1-(2H)-phthalazinone (141123-12-8) → [4-(4-chloro-3-methyl-phenyl)-phthalazin-1-yl]-hydrazine (141123-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅

2: N₂H₄ / ethanol

With phosphorus pentachloride; hydrazine; trichlorophosphate; In ethanol;

Reference yield:

phthalic anhydride (85-44-9) → [4-(4-chloro-3-methyl-phenyl)-phthalazin-1-yl]-hydrazine (141123-38-8)

Guidance literature:

Multi-step reaction with 4 steps

2: 50 percent / NH₂NH₂*H₂O / butan-1-ol / 3 h / Heating

3: 60 percent / PCl₅; POCl₃ / 3 h / Heating

4: 55 percent / NH₂NH₂*H₂O / benzene / 6 h / Heating

With phosphorus pentachloride; hydrazine hydrate; trichlorophosphate; In butan-1-ol; benzene; 1: Friedel-Crafts reaction / 2: Addition / 3: Chlorination / 4: Substitution;

upstream raw materials:

1-chloro-4-(4-chloro-3-methyl-phenyl)-phthalazine

4-(4'-chloro-3'-methylphenyl)-1-(2H)-phthalazinone

phthalic anhydride

2-methylchlorobenzene

Downstream raw materials:

N-[4-(4-Chloro-3-methyl-phenyl)-phthalazin-1-yl]-N'-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazine

4-{[4-(4-chloro-3-methyl-phenyl)-phthalazin-1-yl]-hydrazonomethyl}-2-methoxy-phenol

1-(2',4'-dichlorophenyl)-4-[(4'-chloro-3'-methylphenyl)phthalazin-1-yl]hydrazinoacetonitrile

N-[4-(4-Chloro-3-methyl-phenyl)-phthalazin-1-yl]-N'-[1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-hydrazine

Refernces

• 1、 El-Safty, M. A.,El-Bahaei, S.,El-Hashash, M. A.,El-Farargy, A.,Yasin, F.. "STUDIES IN THE FIELD OF HETEROCYCLIC COMPOUNDS. SYNTHESIS AND BEHAVIOUR OF 4-(4-CHLORO-3-METHYL)PHENYL-1-(2H)-PHTHALAZINONE TOWARDS SOME ELECTROPHILES AND NUCLEOPHILES". . p. 187 - 196. Retrieved 2007/10/03.