optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile

Base Information

• Chemical Name: optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile
• CAS No.: 121545-76-4
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.295
• Mol file: 121545-76-4.mol

Synonyms:

Chemical Property of optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile

There total 1 articles about optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) + phenylacetonitrile (140-29-4) → optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile (121545-76-4)

Guidance literature:

With potassium hydroxide; tetrabutyl ammonium fluoride; lithium perchlorate; In benzene; at 60 ℃; for 1h; Product distribution; Mechanism;

DOI:10.1039/a606498a

Reference yield:

optically inactive (trans-2-hydroxy-cyclohexyl)-phenyl-acetonitrile (121545-76-4) → (3aS,7aR)-3-Phenyl-hexahydro-benzofuran-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O, H⁺

2: Heating

With water; hydrogen cation;

DOI:10.1039/a606498a

upstream raw materials:

cyclohexane-1,2-epoxide

phenylacetonitrile