Technology Process of 2,4,6-Octatrienoic acid,
3,7-dimethyl-8-[3-methyl-2-(1-methylethyl)-2-cyclohexen-1-ylidene]-,
ethyl ester, (Z,E,E,E)-
There total 7 articles about 2,4,6-Octatrienoic acid,
3,7-dimethyl-8-[3-methyl-2-(1-methylethyl)-2-cyclohexen-1-ylidene]-,
ethyl ester, (Z,E,E,E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Zn, 2.) H2O / 1.) benzene, reflux, overnight, 2.) benzene, RT, 2 h
2: 98.5 percent / NaOMe / methanol / 1.5 h / Heating
3: 100 percent / LiAlH4 / diethyl ether / 0.75 h / 0 °C
4: 69 percent / 4 A molecular sieves, MnO2 / CH2Cl2 / 24 h / 0 °C
5: 48 percent / I2 / benzene; hexane / 0.5 h / Ambient temperature
6: 1.) NaH, 2.) HMPA / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 90 min
With
N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; lithium aluminium tetrahydride; 4 A molecular sieve; water; iodine; sodium methylate; sodium hydride; zinc;
In
methanol; diethyl ether; hexane; dichloromethane; benzene;
DOI:10.1021/jm00052a009
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Zn, 2.) H2O / 1.) benzene, reflux, overnight, 2.) benzene, RT, 2 h
2: 98.5 percent / NaOMe / methanol / 1.5 h / Heating
3: 100 percent / LiAlH4 / diethyl ether / 0.75 h / 0 °C
4: 69 percent / 4 A molecular sieves, MnO2 / CH2Cl2 / 24 h / 0 °C
5: 48 percent / I2 / benzene; hexane / 0.5 h / Ambient temperature
6: 1.) NaH, 2.) HMPA / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 90 min
With
N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; lithium aluminium tetrahydride; 4 A molecular sieve; water; iodine; sodium methylate; sodium hydride; zinc;
In
methanol; diethyl ether; hexane; dichloromethane; benzene;
DOI:10.1021/jm00052a009
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 69 percent / 4 A molecular sieves, MnO2 / CH2Cl2 / 24 h / 0 °C
2: 48 percent / I2 / benzene; hexane / 0.5 h / Ambient temperature
3: 1.) NaH, 2.) HMPA / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 90 min
With
N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; 4 A molecular sieve; iodine; sodium hydride;
In
hexane; dichloromethane; benzene;
DOI:10.1021/jm00052a009
