2-Oxa-4,8,13-triazatetradecan-14-oic acid, 1-(4-nitrophenyl)-8-[[(4-nitrophenyl)methoxy]carbonyl]-3-oxo-, (4-nitrophenyl)methyl ester

Base Information

• Chemical Name: 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 1-(4-nitrophenyl)-8-[[(4-nitrophenyl)methoxy]carbonyl]-3-oxo-, (4-nitrophenyl)methyl ester
• CAS No.: 141210-57-3
• Molecular Formula: C31H34N6O12
• Molecular Weight: 682.644
• Mol file: 141210-57-3.mol

Synonyms:

Chemical Property of 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 1-(4-nitrophenyl)-8-[[(4-nitrophenyl)methoxy]carbonyl]-3-oxo-, (4-nitrophenyl)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 1-(4-nitrophenyl)-8-[[(4-nitrophenyl)methoxy]carbonyl]-3-oxo-, (4-nitrophenyl)methyl ester

There total 1 articles about 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 1-(4-nitrophenyl)-8-[[(4-nitrophenyl)methoxy]carbonyl]-3-oxo-, (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) + 4-nitrobenzyl chloroformate (4457-32-3) → N1,N4,N8-tris(4-nitrobenzyloxycarbonyl)-spermidine (141210-57-3)

Guidance literature:

With sodium hydroxide; sodium carbonate; In 1,4-dioxane; at 4 - 20 ℃;

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + N1,N4,N8-tris(4-nitrobenzyloxycarbonyl)-spermidine (141210-57-3) → N1,N8-bis(tert-butoxycarbonyl)-N1,N4,N8-tris(4-nitrobenzyloxycarbonyl)-spermidine (141210-58-4)

Guidance literature:

With dmap; In acetonitrile; for 48h; Ambient temperature;

Reference yield:

N1,N4,N8-tris(4-nitrobenzyloxycarbonyl)-spermidine (141210-57-3) → N1,N8-bis(tert-butoxycarbonyl)-N4-(4-nitrobenzyloxycarbonyl)-spermidine (141210-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DMAP / acetonitrile / 48 h / Ambient temperature

2: 82 percent / N,N'-tetramethylguanidine (TMG) / methanol / Ambient temperature

With dmap; N,N,N',N'-tetramethylguanidine; In methanol; acetonitrile;

upstream raw materials:

N-(3-aminopropyl)-1,4-diaminobutane

4-nitrobenzyl chloroformate

Downstream raw materials:

N¹,N⁸-bis(tert-butoxycarbonyl)-N¹,N⁴,N⁸-tris(4-nitrobenzyloxycarbonyl)-spermidine

N⁴-(4-nitrobenzyloxycarbonyl)-spermidine

N¹,N⁸-bis(tert-butoxycarbonyl)-N⁴-(4-nitrobenzyloxycarbonyl)-spermidine

N¹,N⁸-bis(2,3-dibenzyloxybenzoyl)-N⁴-(4-nitrobenzyloxycarbonyl)-spermidine