1H-Indole-2-carboxylic acid, 5-fluoro-3-(4-fluorophenyl)-, methyl ester

Base Information

Chemical Name:1H-Indole-2-carboxylic acid, 5-fluoro-3-(4-fluorophenyl)-, methyl ester
CAS No.:141306-84-5
Molecular Formula:C16H11F2NO2
Molecular Weight:287.26100
Hs Code.:
Mol file:141306-84-5.mol

Synonyms:5-Fluoro-3-(4-fluoro-phenyl)-1H-indole-2-carboxylic acid methyl ester;

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Chemical Property of 1H-Indole-2-carboxylic acid, 5-fluoro-3-(4-fluorophenyl)-, methyl ester

Chemical Property:

PSA：42.09000
LogP:3.89970

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 1H-Indole-2-carboxylic acid, 5-fluoro-3-(4-fluorophenyl)-, methyl ester

There total 2 articles about 1H-Indole-2-carboxylic acid, 5-fluoro-3-(4-fluorophenyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-Fluoro-phenyl)-2-[(4-fluoro-phenyl)-hydrazono]-propionic acid methyl ester

: 141306-84-5
methyl 5-fluoro-3-(4-fluorophenyl)-1H-indole-2-carboxylate

Guidance literature:: With sulfuric acid; In methanol; for 18h; Heating;
DOI:10.1021/jm00104a007

Reference yield:

: 122255-02-1
methyl 2-(4-fluorobenzyl)-3-oxobutanoate

: 141306-84-5
methyl 5-fluoro-3-(4-fluorophenyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) conc. aq. HCl, NaNO₂, 2.) aq. KOH / 1.) from 0 deg C to 5 deg C, 1.5 h, 2.) ethanol, RT, 2 h

2: conc. H₂SO₄ / methanol / 18 h / Heating

With hydrogenchloride; potassium hydroxide; sulfuric acid; sodium nitrite; In methanol;
DOI:10.1021/jm00104a007

Reference yield:

: 141306-84-5
methyl 5-fluoro-3-(4-fluorophenyl)-1H-indole-2-carboxylate

: 141306-23-2
5-fluoro-3-(4-fluorophenyl)-1-(4-piperidyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 1 h / Heating

2: copper / various solvent(s) / 120 h / Heating

3: K₂CO₃, CuBr / various solvent(s) / 18 h / Heating

4: H₂ / PtO₂ / acetic acid / 72 h / 2280 Torr

With sodium hydroxide; hydrogen; copper; potassium carbonate; copper(I) bromide; platinum(IV) oxide; In methanol; acetic acid;
DOI:10.1021/jm00104a007