2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one

Base Information

• Chemical Name: 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one
• CAS No.: 83206-86-4
• Molecular Formula: C₂₀H₂₀O₇
• Molecular Weight: 372.375
• Mol file: 83206-86-4.mol

Synonyms:

Chemical Property of 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one

There total 10 articles about 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trihydroxytoluene (88-03-9) → 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one (83206-86-4)

Guidance literature:

Multi-step reaction with 5 steps

1: ZnCl₂; HCl / anschliessende Hydrolyse mit H₂O

2: sodium-veratrate / 180 °C / unter vermindertem Druck

3: acetone; potassium carbonate

4: aqueous hydriodic acid

5: acetone; potassium carbonate

With hydrogenchloride; hydrogen iodide; sodium 3,4-dimethoxybenzoate; potassium carbonate; acetone; zinc(II) chloride;

Reference yield:

2-methoxy-1-(2,4,6-trihydroxy-3-methyl-phenyl)-ethanone (110333-13-6) → 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one (83206-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium-veratrate / 180 °C / unter vermindertem Druck

2: acetone; potassium carbonate

3: aqueous hydriodic acid

4: acetone; potassium carbonate

With hydrogen iodide; sodium 3,4-dimethoxybenzoate; potassium carbonate; acetone;

Reference yield:

quercetin 3,3',4'-trimethyl ether (14549-84-9) → 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-8-methyl-chromen-4-one (83206-86-4)

Guidance literature:

Multi-step reaction with 5 steps

1: acetic acid / anschliessend Erwaermen mit wss. Salzsaeure

2: palladium/charcoal; acetic acid / Hydrogenation

3: acetone; potassium carbonate

4: aqueous hydriodic acid

5: acetone; potassium carbonate

With palladium on activated charcoal; hydrogen iodide; potassium carbonate; acetic acid; acetone;

upstream raw materials:

3,5,7,3',4'-pentahydroxy-8-methylflavone

dimethyl sulfate

2-(3,4-dimethoxy-phenyl)-5,7-dihydroxy-3-methoxy-8-methyl-chromen-4-one

2,4,6-trihydroxytoluene