Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester
CAS No.:80980-27-4
Molecular Formula:C₃₄H₃₅N₄O₁₁P
Molecular Weight:706.646
Hs Code.:

Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

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Chemical Property of Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

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Technology Process of Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

There total 3 articles about Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80817-57-8
3'-O-diphenylacetyl thymidine

: 80980-27-4
Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 1.5 h

2: acetonitrile

In acetonitrile;
DOI:10.1246/cl.1981.1725

Reference yield:

: 80973-44-0
Phosphoric acid dibenzotriazol-1-yl ester 4-nitro-phenyl ester

: 80980-27-4
Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[morpholin-4-yl-(4-nitro-phenoxy)-phosphinoyloxymethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 1.5 h

2: acetonitrile

In acetonitrile;
DOI:10.1246/cl.1981.1725