(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

Base Information

Chemical Name:(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline
CAS No.:202263-76-1
Molecular Formula:C₃₆H₄₄F₅NOSi
Molecular Weight:629.829
Hs Code.:

(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

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Chemical Property of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

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Technology Process of (S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

There total 8 articles about (S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 202263-76-1
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH; 18-crown-6

1.2: NH₄QAc

2.1: 45 percent / TFA

3.1: 86 percent / MnO₂

4.1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

5.1: RedAl

6.1: DAST

With manganese(IV) oxide; borane N,N-diethylaniline complex; 18-crown-6 ether; (1R,2S)-1-Amino-2-indanol; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; 4,4'-diaminostilbene-2,2'-disulfonic acid; trifluoroacetic acid;
DOI:10.2533/000942904777678082

Reference yield:

: 4630-80-2
methyl cyclopentane carboxylate

: 202263-76-1
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH; 18-crown-6

1.2: NH₄QAc

2.1: 45 percent / TFA

3.1: 86 percent / MnO₂

4.1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

5.1: RedAl

6.1: DAST

With manganese(IV) oxide; borane N,N-diethylaniline complex; 18-crown-6 ether; (1R,2S)-1-Amino-2-indanol; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; 4,4'-diaminostilbene-2,2'-disulfonic acid; trifluoroacetic acid;
DOI:10.2533/000942904777678082

Reference yield:

: 3-Amino-3-cyclopentyl-1-(4-trifluoromethylphenyl)-propenone

: 202263-76-1
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-3-[(S)-fluoro-(4-trifluoromethyl-phenyl)-methyl]-7,7-dimethyl-5,6,7,8-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 45 percent / TFA

2: 86 percent / MnO₂

3: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

4: RedAl

5: DAST

With manganese(IV) oxide; borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; sodium bis(2-methoxyethoxy)aluminium dihydride; 4,4'-diaminostilbene-2,2'-disulfonic acid; trifluoroacetic acid;
DOI:10.2533/000942904777678082