(S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester

Base Information

• Chemical Name: (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester
• CAS No.: 218606-07-6
• Molecular Formula: C₄₁H₄₁N₄O₈PS
• Molecular Weight: 780.838

Synonyms:

Chemical Property of (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester

There total 1 articles about (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + 3-Hydroxypropionitrile (109-78-4) + methylphosphonothioic dichloride (676-98-2) → (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester (218606-04-3) + (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester (218606-07-6)

Guidance literature:

With pyridine; Multistep reaction; 1.) 55 deg C, 15 min, 2.) room temperature, 30 min;

DOI:10.1021/jo981304v

Reference yield:

(S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester (218606-07-6) → (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester (197578-17-9)

Guidance literature:

Yield given;

DOI:10.1021/jo981304v

Reference yield:

(S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-(2-cyano-ethyl) ester (218606-07-6) → (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester

Guidance literature:

Multi-step reaction with 2 steps

2: 86 percent

DOI:10.1021/jo981304v

upstream raw materials:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

3-Hydroxypropionitrile

methylphosphonothioic dichloride

Downstream raw materials:

(S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

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