6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester
• CAS No.: 855759-01-2
• Molecular Formula: C₂₃H₂₁NO₅
• Molecular Weight: 391.423
• Mol file: 855759-01-2.mol

Synonyms:

Chemical Property of 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester

There total 5 articles about 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-benzyl-5-hydroxy-pyridine-3,4-dicarboxylic acid dimethyl ester; hydrochloride (53381-08-1) → 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester (855759-01-2)

Guidance literature:

With methanol; sodium ethanolate; anschliessendes Erhitzen mit N-Benzyl-N,N-dimethyl-anilinium-chlorid in Methanol und Xylol;

DOI:10.1039/jr9520004386

Reference yield:

benzylamino-3-phenylpropionic acid methyl ester (200435-16-1) → 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester (855759-01-2)

Guidance literature:

Multi-step reaction with 4 steps

2: sodium methylate; methanol / Behandeln des Reaktionsprodukts mit SO₂Cl₂ in Benzol

3: palladium/charcoal; methanol / Hydration

4: sodium ethylate; methanol / anschliessendes Erhitzen mit N-Benzyl-N,N-dimethyl-anilinium-chlorid in Methanol und Xylol

With methanol; palladium on activated charcoal; sodium methylate; sodium ethanolate;

DOI:10.1039/jr9520004386

Reference yield:

2-(benzylamino)-3-phenylpropanoic acid (65027-12-5) → 6-benzyl-5-benzyloxy-pyridine-3,4-dicarboxylic acid dimethyl ester (855759-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol. H₂SO₄

3: sodium methylate; methanol / Behandeln des Reaktionsprodukts mit SO₂Cl₂ in Benzol

4: palladium/charcoal; methanol / Hydration

5: sodium ethylate; methanol / anschliessendes Erhitzen mit N-Benzyl-N,N-dimethyl-anilinium-chlorid in Methanol und Xylol

With methanol; palladium on activated charcoal; sulfuric acid; sodium methylate; sodium ethanolate;

DOI:10.1039/jr9520004386

upstream raw materials:

6-benzyl-5-hydroxy-pyridine-3,4-dicarboxylic acid dimethyl ester; hydrochloride

benzylamino-3-phenylpropionic acid methyl ester

2-(benzylamino)-3-phenylpropanoic acid

N-benzyl-N-(2,3-bis-methoxycarbonyl-propenyl)-phenylalanine methyl ester