Technology Process of (12R)-Lythrancane-8α,12-diol 12-acetate
There total 13 articles about (12R)-Lythrancane-8α,12-diol 12-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at 0 ℃;
for 0.0166667h;
DOI:10.1021/jo00219a061
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) dimethoxyethane, RT, 1 h, 2.) dimethoxyethane, RT, 6 h
2: 71 percent / lithium triethylborohydride / tetrahydrofuran; CH2Cl2 / 0.5 h
3: 92 percent / p-toluenesulfono hydrazide, aq. sodium acetate / 1,2-dimethoxy-ethane / Heating
4: 85 percent / Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 72 h / Ambient temperature
5: 20 percent / tetrakis(triphenylphosphine)nickel(0) / dimethylformamide / 48 h / 55 °C
6: 54 percent / boron tribromide / CH2Cl2 / 0.05 h / 0 °C
With
dmap; tetrakis(triphenylphosphine)nickel(0); sodium acetate; boron tribromide; sodium hydride; lithium triethylborohydride; triethylamine; toluene-4-sulfonic acid hydrazide;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00230a003
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 72 h / Ambient temperature
2: 20 percent / tetrakis(triphenylphosphine)nickel(0) / dimethylformamide / 48 h / 55 °C
3: 54 percent / boron tribromide / CH2Cl2 / 0.05 h / 0 °C
With
dmap; tetrakis(triphenylphosphine)nickel(0); boron tribromide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00230a003
